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GeneGo Services Details
- Knowledge management projects, developing ontologies, controlled vocabularies and infrastructure.
- Disease specific pathway maps.
- Manual curation and annotation of genes, proteins, compounds, drugs, clinical data, protein classes such as kinases, NHR, GPCR’s
- Pathway analysis. Gene list comparisons with reports
- Integration with internal and third party platforms
- Transcription Factor Targets Modeling
- Receptor Targets Modeling
- Transcription Regulation Analysis
- Prioritization of compounds and compound profiling with report
- Identification of targets
- Identification of biomarkers-suggest biomarkers based on disease and target profiling of input list
- Organ-specific toxicity and target evaluation based on structure
- Omics data analysis including gene expression, proteomics, metabolomics, SiRNA, microRNA, etc or a combination of experimental data sets including multiple time points, dosages or treatments
- Analysis of toxicogenomic data to identify perturbed pathways and mechanisms of action
- Identifying key time points at which cell behavior changes most drastically and how in bioconductor experiments.
- Modeling of all putative pathways leading from the receptor target(s) to all differentially expressed genes.
- Connecting top targets proposed by the researchers to explain the pathways they regulate, and how they relate to each other.
- Find therapeutic compounds that target any of your gene lists with references and mechanism of action
- Find common targets for specific compounds or biologics
- Find antibodies that are used therapeutically for genes of interest and relevant indications
- Large scale architecture/infrastructure projects
To discuss custom research and analysis projects please call 858 756 7996 or email
sales@genego.com. A representative will work with you to define the scope, deliverables,
timeline and cost of the project.
Benefits
- Target ranking - support “go” or “no-go” decisions for different possible drug targets
- Compound ranking - support “go” or “no-go” decisions on specific alternative drug
candidates for a specific target
- Combination therapy - support decisions for potential combinations of developmental and existing drugs, or drugs
with activity at multiple targets
- Suggestions for potential molecular biomarkers of disease progression and therapeutic efficacy
- Suggestions for optimal treatment regimes and combination strategies for individual cancer types
- Provide Mechanism of Action for laboratory results that can be used to support patent applications and to gain regulatory
approval.
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“We outsourced prioritization of three compounds to GeneGo. While we understood the effect of these drugs, we needed to prioritize them with respect to biologic potency and possible toxicity. GeneGo's software was able to confirm the biologic activity that we expected and highlighted functional processes and key drug targets that allowed us to focus our testing by suggesting biological activities that could be critical to the success of the candidates, saving us time and money.”