MetaDrug, Systems Pharmacology
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2008
- Integrated Pathway Analysis of Rat Urine Metabolic Profiles and Kidney Transcriptomic Profiles To Elucidate the Systems Toxicology of Model Nephrotoxicants
( Chem Res Toxicol. 2008 Jul 26 )
- Fine-Tuning Compound Safety Assessments
( GEN Vol. 28, No. 6 )
- In Silico Toxicological Screening of Natural Products
( Toxicology Mechanisms and Methods, Volume 18, Issue 2 & 3, pages 229 - 242 )
- Characteristics of Genomic Signatures Derived Using Univariate Methods and Mechanistically Anchored Functional Descriptors for Predicting Drug- and Xenobiotic-Induced Nephrotoxicity
( Toxicology Mechanisms and Methods, Volume 18, Issue 2 & 3, pages 267 - 276 )
- Combined Computational Metabolite Prediction and Automated Structure-Based Analysis of Mass Spectrometric Data
( Toxicology Mechanisms and Methods, Volume 18, Issue 2 & 3, pages 243 - 250 )
- Recursive Partitioning Analysis of Anti-HIV Compounds
( Golden Helix )
2007
2005
- Systems level analysis of drug metabolism and its effects in human biology
( Bioinformatics. 2005, submitted )
- A Combined Approach to Drug Metabolism and Toxicity Assessment
( Drug Metabolism and Disposition 34:495-503, 2006 )
- Reengineering the pharmaceutical industry by crash-testing molecules
( Drug Disc Today, Vol.10 Num. 17, September 2005 )
- Computational prediction of Human Drug Metabolism
( xpert Opinion. Drug Metab. Toxicol. (2005) )
- Techniques: Application of Systems Biology to Absorption, Distribution, Metabolism, Excretion and Toxicity
( TRENDS in Pharmacological Sciences Vol.26 No.4 April 2005 )
- Application of systems biology to absorption, distribution, metabolism, excretion and toxicity
( Trends in Pharmacological Sciences, Vol.26, No.4, 202-209, April 2005 )
- A Novel Method for Visualizing Nuclear Hormone Receptor Networks Relevant to Drug Metabolism
( Drug Metabolism and Disposition, Vol.33, No.3 2005 )
- Comprehensive Computational Assessment of ADME Properties Using Mapping Techniques
( Current Drug Discovery Technologies, 2005, 2, 99-113 )
2004
2003
2002
Mary E. Edgerton, a pathologist performing cancer research at MD Anderson and a long-term client, says “I have been using Metacore for many years in my research into pathways and networks that control aggressive behavior in cancers. I am currently using it to infer networks from analysis of gene expression array data for pathways in lung, brain, and breast cancer. I also use the curated pathways to formulate mathematical models of molecular networks that predict tumor behavior using multiscale modeling. Not only do I find the product to be very useful, but I also appreciate the responsiveness of the staff at Genego to my technical questions and suggestions.”