Gene Expression
Please click on the gene expression references below to read the entire article. Check back occasionally as new gene expression articles will be posted.2007
- Nutrigenomics: concepts and applications to pharmacogenomics and clinical medicine
( Pharmacogenomics. 8(4) 2007 )
- Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening.
( Toxicol. Appl. Pharmacol. (2007), doi:10.1016/j.taap.2007.08.026 )
- Toxicogenomics in the assessment of immunotoxicity
( Methods 41, 132-141, 2007 )
- Chemoinformatics: Theory, Practice, & Products
( Springer, 2007 )
- Lung response to Bordetella pertussis infection in mice identified by gene-expression profiling
( Immunogenetics, accepted )
- In vitro immunotoxicity of bis(tri-n-butyltin)oxide (TBTO) studied by toxicogenomics
( Toxicology 2007, accepted )
- Host transcription profiles upon primary Respiratory Syncytial Virus infection
( Journal of Virology, June 2007, p. 5958-5967 )
- Quantitative proteomic analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer
( Mol Cell Proteomics 12 May 2007 )
- Huntington's disease: from experimental results to interaction networks, patho-pathway construction and disease hypothesis
( BMC Systems Biology 2007, 1(Suppl 1):P45 )
- Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling
( Cancer Res 2007; 67: (7). April 1, 2007 )
- Gene expression response of the rat small intestine following oral Salmonella infection
( Physiol Genomics. 2007 Mar 27 )
- Molecular Definition of Breast Tumor Heterogeneity
( Cancer Cell 11, 259-273, March 2007 )
- High-density rhesus macaque oligonucleotide microarray design using early-stage rhesus genome sequence information and human genome annotations
( BMC Genomics 2007, 8:28 doi:10.1186/1471-2164-8-28 )
2006
- Gene Expression Profiling of Bis(tri-n-butyltin)oxide (TBTO)-Induced Immunotoxicity in Mice and Rats
( Journal of Immunotoxicology, 3:227-244, 2006 )
- Chronic quercetin exposure affects fatty acid catabolism in rat lung
( Cell. Mol. Life Sci. 63 (2006) 2847 - 2858. December 2006 )
- Mass Spectrometry-based Proteomic Studies of Human Anaplastic Large Cell Lymphoma
( Molecular & Cellular Proteomics 5:1787-1798, 2006 )
- Different Signaling Pathways in the Livers of Patients With Chronic Hepatitis B or Chronic Hepatitis C
( HEPATOLOGY, November 2006 )
- Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain
( Physiol Genomics. October 31, 2006 )
- Collaboration with GeneGo provides seamless access to compound databases, patents, literature and biological pathways
( Molecular Connection Vol 24 No 4 2006 )
- Identification of target genes in laryngeal squamous cell carcinoma by high-resolution copy number and gene expression microarray analyses
( Oncogenomics (2006), 1-12 )
- Defective Ribosomal Protein Gene Expression Alters Transcription, Translation, Apoptosis, and Oncogenic Pathways in Diamond-Blackfan Anemia
( Stem Cell, 2006, 24, (9)2034-2044 )
- Evaluation of immunomodulation by Lactobacillus casei Shirota: immune function, autoimmunity and gene expression
( International Journal of Food Microbiology 112, 8-18, 2006 )
- Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells
( Brain Research 1116 (2006) 39-49 )
- Gene Expression profiling of Waldenström&s Macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma
( Blood First Edition Paper, prepublished online June 27, 2006; DOI 10.1182/blood-2006-02-005488 )
- High-protein and high-carbohydrate breakfasts differentially change the transcriptome of human blood cells
( Am J Clin Nutr 2006;84:1233-41 )
- Identification of interactive gene networks: A novel approach in gene array profiling of myometrial events during guinea pig pregnancy
( American Journal of Obstetrics and Gynecology (2006) 194, 1513-23 )
- Microarray Platform Comparisons - Commentary on Barnes et al. (2005)
( Affymetrix White Paper, April 19, 2006 )
- Application of transcriptional and biological network analyses in mouse germ-cell transcriptomes
( Genomics, 2006 )
- Cognitive dysfunction in NF1 knock-out mice may result from altered vesicular trafficking of APP/DRD3 complex
( BMC Neuroscience 2006, 7:22 )
- Biological Pathways at Your Fingertips
( iPath™ Quest Magazine, Vol.3, No.1, 77-81, 2006 )
- Comprehensive Network Analysis of Glaucoma Pathophisiology
( Mol. Sys. Biol. )
2005
- Network analysis of human OMICs data: the toolkit and statistical evaluation
( Proc. Nattl. Acad. Sci. USA )
- Redox proteomic analysis of altered neuronal signaling in a PS1+APP mouse model of Alzheimer's disease
( J. Alzheimer Disease, in press )
- Systems level analysis of drug metabolism and its effects in human biology
( Bioinformatics. 2005, submitted )
- A Toolkit and Statistical Evaluation Method for Network Analysis of Human High Throughput Data
( FEBS Lett 2005, submitted )
- Reengineering the pharmaceutical industry by crash-testing molecules
( Drug Disc Today, Vol.10 Num. 17, September 2005 )
- Use of the local lymph node assay in assessment of immune function
( Toxicology 211, 107-114, 2005 )
- Systems Biology; Applications in drug discovery
( In: Drug Discovery Handbook, Wiley, 2005 )
- Systems Level Network Analysis of OMICs Data
( Gen. Eng. News, 2005, 25, 1, 28-29 )
- Biological networks and analysis of experimental data in drug discovery
( Drug Discovery Today, DDT, Volume 10, Number 9, May 2005 )
- A Novel Method for Generation of Signature Networks as Biomarkers from Complex High Throughput Data
( Tox. Letters 158: 20-29, 2005 )
- Application of systems biology to absorption, distribution, metabolism, excretion and toxicity
( Trends in Pharmacological Sciences, Vol.26, No.4, 202-209, April 2005 )
2004
- Translation research: from accurate diagnosis to appropriate treatment
( Journal of Translational Medicine 2004, 2:35 )
- Kohonen Maps for Prediction of Binding to Human Cytochrome P450 3A4
( Drug Metabolism and Disposition, DMD 32:1183-1189, 2004 )
- Early Prediction of Drug Metabolism and Toxicity: Systems Biology Approach and Modeling
( Drug Discovery Today, DDT Vol.9, No.3, February 2004 )
2003
- Modeling of Human Cytochrome P450-Mediated Drug Metabolism Using Unsupervised Machine Learning Approach
( Journal of Medicinal Chemistry, 46: 3631-3643, 2003 )
Mary E. Edgerton, a pathologist performing cancer research at MD Anderson and a long-term client, says “I have been using Metacore for many years in my research into pathways and networks that control aggressive behavior in cancers. I am currently using it to infer networks from analysis of gene expression array data for pathways in lung, brain, and breast cancer. I also use the curated pathways to formulate mathematical models of molecular networks that predict tumor behavior using multiscale modeling. Not only do I find the product to be very useful, but I also appreciate the responsiveness of the staff at Genego to my technical questions and suggestions.”