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Biomarkers
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2010
- Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome
( BMC Cancer 2010, 10:506 )
Background Osteosarcoma (OSA) spontaneously arises in the appendicular skeleton of large breed dogs and shares many physiological and molecular biological characteristics with human OSA. The standard treatment for OSA in ...
- Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
( J Proteomics. 2010 Jun 16;73(8):1612-31 )
The transcription factor Nrf2 regulates expression of multiple cellular defence proteins through the antioxidant response element (ARE). Nrf2-deficient mice (Nrf2(-/-)) are highly susceptible to xenobiotic-mediated toxicity, but the precise molecular ...
- Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes
( The Pharmacogenomics Journal (2010) 10, 310–323 )
Gene expression signatures of toxicity and clinical response benefit both safety assessment and clinical practice; however, difficulties in connecting signature genes with the predicted end points have limited their application. ...
- Genomic indicators in the blood predict drug-induced liver injury
( The Pharmacogenomics Journal (2010) 10, 267–277 )
Genomic biomarkers for the detection of drug-induced liver injury (DILI) from blood are urgently needed for monitoring drug safety. We used a unique data set as part of the Food ...
- Proteomics, bioinformatics and targeted gene expression analysis reveals up-regulation of cochlin and identifies other potential biomarkers in the mouse model for deafness in Usher syndrome type 1F
( Hum Mol Genet. 2010 Apr 15;19(8):1515-27 )
Proteins and protein networks associated with cochlear pathogenesis in the Ames waltzer (av) mouse, a model for deafness in Usher syndrome 1F (USH1F), were identified. Cochlear protein from wild-type and ...
- Change in amniotic fluid levels of multiple anti-angiogenic proteins before development of preeclampsia and intrauterine growth restriction
( J Clin Endocrinol Metab. 2010 Mar;95(3):1431-41 )
Context: The cause of preeclampsia remains unknown. Excessive antiangiogenic proteins have been proposed to play a pathogenic role in preeclampsia. Objective: Our objective was to determine the differences in soluble ...
- Eight-plex iTRAQ analysis of variant metastatic human prostate cancer cells identifies candidate biomarkers of progression: An exploratory study.
( The Prostate )
BACKGROUND: Due to the heterogeneity in the biological behaviour of prostate cancer, biomarkers that can reliably distinguish indolent from aggressive disease are urgently needed to inform treatment choices. METHODS: We ...
- Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats
( Am J Physiol Renal Physiol. 2010 Jan 13 )
To clarify the specific molecular events of progressive tubular damage in chronic renal failure (CRF), we conducted microarray analyses using isolated proximal tubules from subtotally nephrectomized (Nx) rats as a ...
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Mary E. Edgerton, a pathologist performing cancer research at MD Anderson and a long-term client, says “I have been using Metacore for many years in my research into pathways and networks that control aggressive behavior in cancers. I am currently using it to infer networks from analysis of gene expression array data for pathways in lung, brain, and breast cancer. I also use the curated pathways to formulate mathematical models of molecular networks that predict tumor behavior using multiscale modeling. Not only do I find the product to be very useful, but I also appreciate the responsiveness of the staff at Genego to my technical questions and suggestions.”