Included in MetaCore

MetaSearch™ Overview

MetaSearch is a powerful tool for querying GeneGo’s manually curated MetaBase content in an intuitive interface. Users can run custom Boolean queries that narrow down over 6 million “findings” in the database to the most relevant for their research data.

The resulting list may include genes, proteins, compounds, drugs, specific pathways or many other entities that satisfy the conditions of the query. These conditional parameters can be anything from biological process categories to tissues to disease areas or to types of interaction mechanisms and their directionality.

Moreover, MetaSearch results can be used for further knowledge mining with available 1-click options for building networks or activating the results as a new list or experiment file in MetaCore. Such files can be used for any of our workflows, interactome analysis, and for comparisons and intersections with other lists of interest that may come from custom data sets or saved list files from other results in MetaCore. MetaSearch provides a set of ready to use queries that can be used as examples or templates to be further modified for various types of analyses.

In seconds MetaSearch can answer questions such as:

• Which drugs are in clinical trials for GBM that are already FDA approved for any other cancers?
• What are the genes that are regulated by specific microRNAs that are also associated with hepatocellular carcinoma, but are NOT part of a cell cycle process?
• What are all the therapeutic targets associated with arterial occlusive diseases that are NOT related to obesity?
• Which human proteins are known to get phosphorylated and activated by kinases that are expressed in the brain?
• Which compounds inhibit gene A but NOT gene B via direct binding and with IC50<1uM?
• Which extracellular ligands are regulated by NF-kB and by AP-1 transcription complexes?
• Which are the cytosolic enzymes involved in metabolic processes in rodents, but NOT in humans, which are also contained on at least 1 GeneGo Canonical Pathway Map?