Included in MetaCore

MetaRodent™ Overview - species specific pathway analysis

MetaRodent™ database is part of MetaCore, MetaDrug and other products, providing a unique animal model comparison capability for disease research and systems toxicology. MetaRodent™ is based on a unique, proprietary, manually-curated database of human, mouse, and rat-specific protein-protein, protein-nucleic acid and protein-compound interactions. MetaRodent™ allows functional analysis of genomic, metabolomic, proteomic, siRNA and other information-rich screening data, in order to discover pathway-linked biomarkers and drug targets, or evaluate system-level effects of bioactive compounds, including indications, side effects and toxicity. Importantly, MetaRodent™ mouse and rat content does not derive from orthologous gene matching between rodent and human, but on the specific manual curation of rodent genes, proteins, protein complexes, protein function, transcriptional regulation, etc. from experimental literature. MetaRodent™ enables direct comparison between metabolism, signaling, and cellular processes in human and model organisms. In addition to species-specific content, the MetaRodent™ database allows comparative analysis, via ortholog mapping, including other eukaryotic species.

MetaRodent™ is equipped with intuitive tools for the comprehensive functional analysis and visualization of data, taking full account of the differences between human and rodent biology. This is a critical feature, allowing the evaluation of multiple types of systems biology data from experiments in model species, while facilitating the appropriate interpretation of the outcome with respect to the potential effects in man.

Key Features:

• The only mouse and rat network and pathway analysis platform based on species-specific annotation of interactions rather than on orthologs
• Import and export of mouse or rat experimental data in species-specific format (no ortholog format restrictions)
• Conversion between mouse, human and rat gene and protein IDs
• Direct parsing of mouse and rat arrays
• Mouse and rat-specific canonical pathways
• Mouse and rat-specific protein complexes
• Visualization of species-specific genes and interactions between them, on maps and networks
• All interaction references are highlighted for human, mouse or rat
• MetaRodent™ utilizes the complete content and toolbox of MetaCore™