MetaBase™ (direct access to content)

MetaBase™ is the knowledge base behind all GeneGo products including MetaCore™ and MetaDrug™. Organized as an Oracle database with over 100 tables, MetaBase™ is, arguably, the most comprehensive manually curated source of mammalian biology and medicinal chemistry data available today. Overall, it contains over 6 million experimental findings on protein-protein, protein-DNA and protein-compound interactions. MetaBase™ also includes thousands of established “canonical” signaling and metabolic pathways, ligand-receptor binding data for drugs and bioactive compounds, drug targets and diseases, kinetic information for drug-metabolizing enzymes and relevant signaling proteins. The data is organized in multiple ontologies with semantic consistency supported by a controlled vocabulary with 7 million synonyms. GeneGo offers access to MetaBase™ tables and schema to a select group of large life science organizations for pursuits in disease research, drug discovery, genomics, metabolomics, proteomics and more. Customers can integrate MetaBase™ content with their internal system and edit the interaction information. MetaBase™ can also be used as a central repository for experimental data, integrated with internal databases and algorithms and distributed enterprise wide within the organization. MetaBase™ is installed behind the user’s firewall on a stand-alone server. The product is made available at GeneGo’s discretion.

MetaBase™ provides customers with direct access GeneGo’s content.

• The largest manually curated database of mammalian biology and medicinal chemistry
• Oracle based and requires Oracle RDBMS 9.2 or higher.
• Easy installation and update
• Quarterly updates

MetaBase™ contains data in the following categories:

Physical entities:

• Genes
• Proteins
• Chemical compounds
• Enzymes

Interaction data:

• Signaling and Metabolic networks
• Chemical reactions

Other data:

• Public domain and proprietary ontologies and controlled vocabulary with over 7 million synonyms
• Protein interactions and causal disease associations for over 20,000 human proteins
• Gene, protein and compound mapping to public identifiers
• Protein hierarchy, complexes, families
• Canonical pathway maps: signaling, metabolic, pathology, disease pathways
• Tissue expression, protein abundance, subcellular localizations

MetaBase enables research into proteomics, genomics, metabolomics and more through our manually curated database of mammalian biology and medicinal chemistry.