Pathway Map DetailsIL-1 beta-dependent CFTR expression
Object list (links open in MetaCore):TAK1(MAP3K7), IL-1RI, TRAF6, TAB1, CFTR, NF-kB p50/p65, TAB2, IL-1 beta, IRAK1/2, TOLLIP, MyD88, IL1RAP, IKK, IRAK4, NIK(MAP3K14), I-kB Description:
IL-1 beta-dependent CFTR expression Interleukin 1 ( IL-1 beta ) stimulates expression of the Cystic fibrosis transmembrane conductance regulator ( CFTR ) via Nuclear factors of kappa light polypeptide in B-cells ( NF-kB ). The exact signaling leading to CFTR expression is unknown. The basic pathway of NF-kB activation by IL-1 beta is mediated by TNF receptor-associated factor 6 ( TRAF6 ). IL-1 binds to Interleukin 1 receptor type I ( IL-1RI ) and activates transcription factors via cytoplasmic mediators such as myeloid differentiation primary response gene ( MyD88 ), IL-1 receptor-associated kinase ( IRAK ) and TRAF6 [1], [2]. These intracellular processes result in recruitment and activation of I kappa B kinases complex ( IKK ). IKK phosphorylates NF-KB inhibitor ( I-KB ) and thereby marks it for degradation, consequently leading to increase in DNA-binding activity of the NF-kB [3] that directly activates transcription of CFTR [4], [5]. References:
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