Case Studies

MetaCore

• Breast Cancer - Network Analysis of Breast Cancer Gene Clusters
• Combining Agile Text Mining with Expert Manually Curated Data to Provide Enhanced Understanding of Liver Fibrosis
• Cystic Fibrosis - Inflammation and CFTR trafficking
• Diabetes - Understanding Insulin-Resistant Diabetes Through Pathway Analysis
• HCV - Discovering Molecular Pathways of HCV
• Investigating mechanisms of toxicity of the environmental pollutant PFOA using the Toxicity Analysis and Interactome tools
• Metabolomics - Pathway Analysis of Serological Metabolite Profiles in Rheumatoid Arthritis
• Pathway Analysis of Genome-Wide Association Studies (GWAS) in Parkinson’s Disease
• Psoriasis - Discovering Molecular Pathways of Psoriasis
• MetaLink, microRNA - Network Analysis of MicroRNA
• MetaLink, Parkin - Network Analysis of protein interactions of Parkin in the brain

MetaDrug

• Clozapine - A chemogenomic approach to understanding the side effects of the former front-line anti-psychotic drug clozapine, and comparison to the structurally similar anti-psychotic drug olanzapine
• Environmental Toxicants - In silico prediction of the biological effects of propiconazole
• Mebendazole - Investigation of potential antineoplastic activity of the anthelmintic drug mebendazole

Video Case Studies

• Vioxx® - drug repurposing, side effects (3:12 min)
• Mebendazole - MOA, expression data, repurposing (3:24 min)
• Alzheimer’s drugs - drug comparison, off-target effects (2:58 min)
• Stem cell proliferators - chemical library profiling, MOA, toxicity (3:32 min)