February 21st: Pathway Analysis of Genome-Wide Association Studies (GWAS)in Parkinson.s Disease using MetaCore
September 28th
Scientific Webinar
Identifying molecular pathway signatures for the growth and maintenance of human CD 44+/24- stem cell-like breast cancer cell populations.
10am San Francisco | 1pm New York
February 6th
MetaDrug 11am EST: Getting started with MetaDrug: from compound structure to pharmacological activity Register
MetaCore 1pm EST: etting started with MetaCore: Getting the most from your “omics” Analysis Register
February 2121
MetaCore 1pm EST: Pathway Analysis of Genome-Wide Association Studies (GWAS) in Parkinson.s Disease using MetaCore Register
- GeneGo is Awarded NCI Grant for Development of Systems Biology Platform for Integrative Data Analysis in Cancerpetitive Strategy Leadership Award...
- January 1, 2011
- Thomson Reuters acquires GeneGo ...
- June 10, 2010
- GeneGo Publication Designated Highly Accessed by BioMed Central ...
“Biologist see the importance of looking at the circuitry rather than just simple wiring. That is why MetaCore™ interactions are so much more powerful as they have directionality, show effect and mechanism of interaction all validated with papers one click away”.
“We compared several platforms before we finally decided on GeneGo. MetaCore™ has broad and deep, high quality content coverage, which was important to us. Furthermore its ability to work with mixed ID's is critical for our internal R&D work and service offerings based on our unique DSA™ (patent pending) research tools” said Dr Vitali Proutski, Bioinformatics Manager at Almac Diagnostics. “We were also very impressed by GeneGo's responsiveness and strong customer support which we feel is vital in relationships with our partners.”
More on GeneGo’s pathway analysis tools...Click here for more information.
Sodium arsenite dependent protein expression analysis on human embryonic carcinoma (NCCIT) cell line | read
TOXICOLOGY LETTERS 207 (2): 149-158 10.1016
Due to their pluripotent nature, embryonic carcinoma (EC) cell lines are useful for the study of basic and applied aspects of medical therapeutics, disease management and environmental mutagenesis. We evaluated the teratogenic like effects of inorganic arsenic during the early stages of cellular development in NCCIT cells, a type of human EC cells. Using matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and MetaCore pathway analysis software (GeneGo), the proteomic expression profiles of NCCIT cells after either short- or long-term sodium arsenite (NaAsO(2)) treatment and of NCCIT cell-derived embryoid bodies (EBs) after short-term NaAsO(2) treatment were studied to determine the toxic effects on the process of normal growth and differentiation. The protein expression profiles of the NaAsO(2)-treated NCCIT cells and EBs were compared with that of untreated NCCIT cells. Short-term NaAsO(2) treatment resulted in the down-regulation of most proteins, with heat shock 90-kDa protein (HSP90) and valosin-containing protein (VCP) being significantly downregulated. Long-term NaAsO(2) treatment caused marked up-regulation of B23/nucleophosmin, glucose regulated protein 78-kDa (GRP78), unc-51-like kinase 3 (ULK3), toll-like receptor 6 precursor (TLR6) and mitogen-activated protein kinase 7 isoform A (MAP3K7). NaAsO(2) treatment of the NCCIT cell-derived EBs resulted in the down-regulation of several tumor-suppressor proteins. Taken together, these data suggest that a wide spectrum of cellular responses is induced to cope with chronic non-lethal toxic stresses in NCCIT cells.
Vioxx® - drug repurposing, side effects (3:12 min)
Mebendazole - MOA, expression data, repurposing (3:24 min)
Alzheimer’s drugs - drug comparison, off-target effects (2:58 min)
Stem cell proliferators - chemical library profiling, MOA, toxicity (3:32 min)
Edited by Yuri Nikolsky and Julie Bryant, GeneGo, Inc.
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GeneGo’s unique systems reconstruction technology for systems biology enables complete reconstruction of mammalian cellular functionality from high fidelity “benchmark” interactions data at all three levels:
Stimuli (ligand-receptor interactions)
Cell signaling and regulation
Effect (core metabolism)
Through our pathway analysis software & knowledge mining applications, experimental data is analyzed in our systems reconstruction framework to deduce the pathways, genes, proteins and metabolites most relevant for the disease and condition.