March 7-11, 2010

SOT Annual Meeting, Salt Lake City, UT

April 13-16, 2010

4th International Conference on Primate Genomics, Seattle, WA

MetaCore 6.0 is here with a NEW EASIER to use interface! | Read more

NEW from GeneGo... Eureka! For knowledge mining of GeneGo‘s high quality manually curated content | Read more

Scientific Webinar
February 22, 2010 1:00 pm EST
Networking with pathway and text-mining tools : A case study on pathways in mouse and human lupus
Dr. Padma Reddy
Principal Research Scientist I - Pfizer| Read more

GeneGo is Awarded NCI Grant for Development of Systems Biology Platform for Integrative Data Analysis in Cancerpetitive Strategy Leadership Award...

January 8, 2010

GeneGo Reinforces E-Commerce Efforts with Sigma-Aldrich, Signs First Software Distribution Deal ...

June 1, 2009

GeneGo Sponsored Seminar at Northwestern University in Chicago ...

“Biologist see the importance of looking at the circuitry rather than just simple wiring. That is why MetaCore™ interactions are so much more powerful as they have directionality, show effect and mechanism of interaction all validated with papers one click away”.

“We compared several platforms before we finally decided on GeneGo. MetaCore™ has broad and deep, high quality content coverage, which was important to us. Furthermore its ability to work with mixed ID's is critical for our internal R&D work and service offerings based on our unique DSA™ (patent pending) research tools” said Dr Vitali Proutski, Bioinformatics Manager at Almac Diagnostics. “We were also very impressed by GeneGo's responsiveness and strong customer support which we feel is vital in relationships with our partners.”

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Try the New Hidden Nodes Algorithm
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Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats | read
Am J Physiol Renal Physiol. 2010 Jan 13

To clarify the specific molecular events of progressive tubular damage in chronic renal failure (CRF), we conducted microarray analyses using isolated proximal tubules from subtotally nephrectomized (Nx) rats as a model of CRF. Our results clearly demonstrated time-dependent changes in gene expression profiles localized to proximal tubules. The expression of mitosis-specific genes Cyclin B2 and Cell division cycle 2 (Cdc2) was significantly and selectively increased in the proximal tubules during the compensated period but decreased to the basal level in the end-stage period. Administration of everolimus, a potent inhibitor of mammalian target of rapamycin, markedly reduced compensatory hypertrophy and hyperplasia of epithelial cells, which was accompanied by complete abolishment of the expression of Cyclin B2 and Cdc2 enhancement; renal function was then severely decreased. Treatment with the Cdc2 inhibitor, 2-cyanoethyl alsterpaullone, clearly decreased epithelial cell hyperplasia, based on staining of phosphorylated histone H3 and Ki-67, while hypertrophy was not inhibited. In conclusion, we have demonstrated roles of Cyclin B2 and Cdc2 in the epithelial hyperplasia in response to Nx. These results advanced the knowledge of the contribution of cell cycle regulators, especially M phase, in pathophysiology of tubular restoration and/or degeneration, and these two molecules are suggested to be a marker for the proliferation of proximal tubular cells in CRF. Key words: Proximal tubule, Microarray, Cell Cycle, G2-M.

OmicSoft products now available from GeneGo... Get your FREE Trial today | Read more

 

Edited by Yuri Nikolsky and Julie Bryant, GeneGo, Inc.

Available on Amazon.com

Job postings for Systems Biology careers in the community.

 

GeneGo and the Cystic Fibrosis Foundation collaborated to develop a unique cystic fibrosis pathway analysis platform as part of GeneGo's MetaMiner disease specific partnership program. For more details on this bioinformatics software application please download the white paper.

If you would like to make a donation to the Cystic Fibrosis Foundation to help find a cure please click here

Bioinformatics Software & Pathway Analysis Applications

GeneGo’s unique bioinformatics software technology for systems biology enables complete reconstruction of mammalian cellular functionality from high fidelity “benchmark” interactions data at all three levels:

Stimuli (ligand-receptor interactions)
Cell signaling and regulation
Effect (core metabolism)
Through our bioinformatics software & data mining applications, experimental data is analyzed in our systems reconstruction framework to deduce the pathways, genes, proteins and metabolites most relevant for the disease and condition.